Processing, purity, and the path to restoration

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Beyond the Itch: Fresh Thinking on Allergy Management

Nutrition is not just about ingredients – it’s also about how it’s cooked. Processing can transform nutrients into powerful allies or hidden antagonists, shaping the systemic immune response at the cellular level.

In the final part of our Beyond the Itch: Fresh Thinking on Allergy Management series, we unpack how cooking temperature, ingredient integrity, and protein purity influence tolerance, client trust, and long-term outcomes. Our goal: to move from symptom control toward genuine restoration.


Processing matters

High-heat extrusion generates Maillard Reaction Products and Advanced Glycation End-Products (AGEs)1 – compounds that amplify oxidative stress, alter the microbiome, and can modify proteins in ways that promote intolerance.

While processing is necessary to an extent to control pathogen risks, cooking at moderate temperatures (around 90°C) appears to preserve nutrient integrity and kill food-borne pathogens, while limiting AGE formation. In controlled cross-over studies, plasma AGE concentrations were significantly lower in dogs receiving gently-cooked food than those fed canned or extruded diets.2

“Minimally processed diets – raw diets and fresh diets – compared with processed diets, like extruded kibble or canned diets, can affect the spectrum of the microbiome, the balance and the diversity of the microbes living there.” – Dr Laura Gaylord


Palatability and purity: the basis of diagnostic confidence

Client compliance remains the main limiting factor to conducting an effective elimination diet3, with a large proportion of dog owners continuing to allow access to alternative food sources throughout the trial.4 

In an online survey collected from 93 owners with dogs that underwent an elimination diet, 75% of the participating clients reported dietary indiscretions (fruits, vegetables, meats, dairy, bread), 51% reported provision of additional food sources, and 25% of dogs were reported to have access to unmonitored food sources including cat litter boxes and garbage during the trial.

Gentle cooking maintains palatability compared to hydrolyzed diets, which is an often-overlooked factor in compliance. In an independent, third-party feeding trial, dogs preferred Hypoallergenic Pro 2:1 over a popular hydrolysed option, consuming 90% more food.

Even with good compliance, accurate diagnosis in food sensitivity depends on true single-protein diets. Yet independent analyses reveal that nearly half of “novel protein” veterinary diets contain undeclared ingredients, and more than half include soy or other contaminants.5 

These inconsistencies turn elimination trials into guesswork, and risk undermining our clients’ trust in our diagnostic process.

Rigorous production standards, including human-grade facilities, HACCP certification, and PCR-verified protein purity, are required to produce a diet suitable for conducting an elimination trial with confidence. When clinicians can trust what’s in the bowl, they can interpret outcomes with precision.


Toward a restorative model of care

These findings converge on a simple but powerful idea: the health of the skin begins in the gut. A therapeutic diet should not just minimise exposure but maximise recovery. By supporting microbial diversity, reinforcing barrier function, and modulating systemic inflammation, fresh formulations can help restore homeostasis rather than merely suppress signs.

  • Less restriction, more restoration.

  • Less reactivity, more resilience.

  • Less symptom control, more systemic balance.

“Integrative nutrition means we’re thinking beyond just avoiding antigens in the diet. We’re really trying to pull in nutrients here that help us manage all of these aspects… to manage both gut and skin signs.” – Dr Laura Gaylord

When the problem starts in the gut, so must the solution.


About Lyka Hypoallergenic Pro

Gently cooked at 90 °C in human-grade, HACCP-certified facilities, Lyka Hypoallergenic Pro preserves nutrients while limiting Maillard reaction products and advanced glycation end-products. Every batch is PCR-verified for single-protein purity, ensuring true diagnostic confidence in elimination trials. The result is nutrition that supports barrier health, lowers oxidative stress, and delivers consistent clinical outcomes.


Webinar

👉 Watch the full webinar, Beyond the Itch: Fresh Thinking on Allergy Management with Dr Laura Gaylord, and learn more about Lyka Hypoallergenic Pro – real food that protects purity and promotes recovery.

References

  1. Food Processing: The Influence of the Maillard Reaction on Immunogenicity and Allergenicity of Food Proteins (2017)

  2. Association of four differently processed diets with plasma and urine advanced glycation end products and serum soluble receptor for advanced glycation end products concentration in healthy dogs (2024)

  3.  Patch testing and allergen-specific serum IgE and IgG antibodies in the diagnosis of canine adverse food reactions (2012)

  4. Assessment of dog owners' knowledge relating to the diagnosis and treatment of canine food allergies (2019)

  5. Identification of undeclared sources of animal origin in canine dry foods used in dietary elimination trials (2013)

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